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Indications

BEERS REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: rash.

EENT: blurred vision.

GI: constipation, diarrhea, nausea, vomiting.

Neuro: hangover, abnormal thinking, behavior changes, dizziness, drowsiness, hallucinations, lethargy, paradoxic excitation, sleep driving.
Misc: physical dependence, psychological dependence.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

US Brand Names

Restoril

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: sedative/hypnotics

Pharmacologic Classification: benzodiazepines

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed; crosses blood-brain barrier. Probably crosses the placenta and enters breast milk. Accumulation of drug occurs with chronic dosing.

Protein Binding: 96%.

Metabolism/Excretion: Metabolized by the liver.

Half-life: 10–20 hr.

Contr. Subst. Schedule

Schedule IV (C-IV)

Time/Action Profile

(sedation)

ROUTEONSETPEAKDURATION
PO30 min2–3 hr6–8 hr

Patient/Family Teaching

Pronunciation

tem-AZ-a-pam