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Indications

REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.

EENT: red discoloration of tears.

GI: abdominal pain, diarrhea, flatulence, heartburn, nausea, vomiting, HEPATOTOXICITY, red discoloration of saliva and teeth.

GU: red discoloration of urine.

Hemat: bleeding, hemolytic anemia, thrombocytopenia, THROMBOTIC MICROANGIOPATHY (INCLUDING THROMBOTIC THROMBOCYTOPENIC PURPURA AND HEMOLYTIC UREMIA SYNDROME).

MS: arthralgia, muscle weakness, myalgia.

Neuro: ataxia, confusion, drowsiness, fatigue, headache, weakness.

Resp: INTERSTITIAL LUNG DISEASE.
Misc: flu-like syndrome, (INCLUDING ANGIOEDEMA)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Tuberculosis

Asymptomatic Carriers of Meningococcus

H. influenzae Prophylaxis

Synergy for S. aureus Infections

US Brand Names

Rifadin, Rimactane

Action

Therapeutic Effects:

Spectrum:

Classifications

Therapeutic Classification: antituberculars

Pharmacologic Classification: rifamycins

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed; enters CSF.

Protein Binding: 80%.

Metabolism/Excretion: Mostly metabolized by the liver; 60% eliminated in feces via biliary elimination.

Half-life: 3 hr.

Canadian Brand Names

Rofact

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POrapid2–4 hr12–24 hr
IVrapidend of infusion12–24 hr

Patient/Family Teaching

Pronunciation

rif-AM-pin