- One unit/kg body weight will ↑ Factor VIII level by 2%.
Control/prevention of bleeding episodes
- IV (Adults and Children ≥6 yr): Minor or moderate bleeding (requires Factor VIII level of 4060% of normal): 2030 IU/kg every 2448 hr until bleeding episode is resolved; Major bleeding (requires Factor VIII level of 80100% of normal): 4050 IU/kg every 1224 hr until bleeding episode is resolved (710 days).
- IV (Children <6 yr): Minor or moderate bleeding (requires Factor VIII level of 4060% of normal): 2030 IU/kg every 12 hr un-24 until bleeding episode is resolved; Major bleeding (requires Factor VIII level of 80100% of normal): 4050 IU/kg every 824 hr until bleeding episode is resolved (710 days).
Perioperative Management
- IV (Adults and Children ≥6 yr): Minor prodecures (requires Factor VIII level 5080% of normal): 2540 IU/kg every 24 hr for 24 hr until healing is achieved; major prodecures (requires Factor VIII level 80120% of normal): 4060 IU/kg pre-operatively followed by 4050 IU/kg after 824 hr and then every 24 hr to maintain Factor VIII level in desired range, continued until wound healing and then for at least 7 days to maintain Factor VIII level in desired range.IV (Children <6 yr): Minor prodecures (requires Factor VIII level 5080% of normal): 2540 IU/kg every 1224 hr for 24 hr until healing is achieved; major prodecures (requires Factor VIII level 80120% of normal): 4060 IU/kg pre-operatively followed by 4050 IU/kg after 624 hr and then every 24 hr to maintain Factor VIII level in desired range, continued until wound healing and then for at least 7 days to maintain Factor VIII level in desired range.
Routine prophylaxis
- IV (Adults and Children ): 50 IU/kg every 4 days (range 2565 IU/kg every 35 days), doses up to 80 IU/kg or more frequent doses may be required in children <6 yr.
Therapeutic Classification: hemostatic agents
Pharmacologic Classification: clotting factors replacements
Absorption: IV administration results in complete bioavailability.
Distribution: Unknown.
Metabolism/Excretion: Unknown.
Half-Life: Unknown; clearance is more rapid in children.
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