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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema, hypotension, tachycardia, HF, palpitations.

Derm: hirsutism, rash.

Endo: hyperglycemia, DIABETIC KETOACIDOSIS, HYPEROSMOLAR NONKETOTIC COMA, hyperuricemia.

GI: abdominal pain, diarrhea, ILEUS, loss of taste, nausea, vomiting.

GU: glycosuria.

Hemat: neutropenia, thrombocytopenia.

MS: weakness.

Neuro: headache.

Resp: PULMONARY HYPERTENSION.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

see Calculator

Hyperinsulinemic Hypoglycemia

US Brand Names

Proglycem

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: hyperglycemic

Pharmacologic Classification: pancreatics

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Crosses the blood-brain barrier and placenta.

Protein Binding: >90%.

Metabolism/Excretion: 50% metabolized by the liver; 50% excreted unchanged by the kidneys.

Half-life: 10–36 hr ( in renal impairment).

Time/Action Profile

(Blood glucose concentrations)

ROUTEONSETPEAKDURATION
PO1 hr8–12 hr8 hr

Patient/Family Teaching

Pronunciation

dye-az-OX-ide