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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

GI: amylase, liver enzymes, abdominal pain, LACTIC ACIDOSIS/HEPATOMEGALY WITH STEATOSIS, nausea.

GU: ACUTE RENAL FAILURE/FANCONI SYNDROME, glycosuria.

Metab: hyperlipidemia.

MS: creatine kinase, back pain.

Neuro: fatigue, headache.

Resp: cough.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

Route/Dosage

Renal Impairment

US Brand Names

Vemlidy

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: nucleoside reverse transcriptase inhibitors

Pharmacokinetics

Absorption: Tenofovir alafenamide is a prodrug, which is hydrolyzed into tenofovir; absorption enhanced by high-fat meals.

Distribution: Unknown.

Metabolism/Excretion: Tenofovir is phosphorylated to tenofovir diphosphate (active metabolite); 32% excreted in feces, <1% in urine.

Half-life: 0.51 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown0.5 hr24 hr

Patient/Family Teaching

Pronunciation

te-NOE-fo-veer al-a-FEN-a-mide