centruroides (scorpion) immune f(ab’)2 (equine) injection

REMS

Treatment of clinically important signs of scorpion envenomation which may include loss of muscle control, roving/abnormal eye movements, slurred speech, respiratory distress, excessive salivation, frothing at the mouth and vomiting.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

No contraindications noted.

Use Cautiously in:

Known allergies to horse protein (↑ risk of serious hypersensitivity reactions); sensitization may develop from previous treatment;
Lactation: Use cautiously, secretion into breast milk is not known;
OB: Use during pregnancy only if clearly needed.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: pruritus, rash

EENT: rhinorrhea

GI: nausea, vomiting, diarrhea

Local: localized reactions (from cresol excipient)

MS: generalized myalgias (from cresol excipient), myalgia

Neuro: fatigue, headache, lethargy

Resp: cough

Misc: fever, delayed hypersensitivity reactions including serum sickness, severe hypersensitivity reactions including anaphylaxis

Interactions ⬆ ⬇

Drug-drug:

None noted.

Availability ⬆ ⬇

Lyophilized powder for injection (requires reconstitution) made from equine plasma: not more than 120 mg total proteint and not less than 150 LD₅₀(mouse) neutralizing units/vial

Route/Dosage ⬆ ⬇

IV (Adults ): 3 vials initially, followed by 1 vial every 30–60 min as needed.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Binds/neutralizes venom toxins, promoting removal from target tissues and elimination.

Therapeutic effects:

Resolution of symptoms of envenomation.

Classifications ⬆ ⬇

Therapeutic Classification: antidotes

Pharmacologic Classification: antivenom

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability

Distribution: Unknown.

Metabolism/Excretion: Unk.

Half-Life: 159 hr.

Time/Action Profile ⬆ ⬇

(resolution of systemic symptoms)

ROUTE	ONSET	PEAK	DURATION
IV	within 4 hr	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose of medication to patient.
Instruct patient to notify health care professional or emergency department immediately if signs and symptoms of delayed reactions (rash, pruritus, joint pain, fever, lymphadenopathy, malaise) occur. May occur for up to 14 days following treatment.
Advise female patient to notify health care professional if pregnant or pregnancy is suspected, or if breastfeeding.

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Indications ⬇