antihemophilic (recombinant), porcine sequence

REMS

Contraindicated in:

Life-threatening hypersensitivity reactions to this product or any of its components (including hamster protein).

Use Cautiously in:

Misc: development of inhibitory antibodies to porcine factor VIII, ANAPHYLAXISALLERGIC REACTIONS INCLUDING

Drug-drug:

Bleeding may be ↑ by aspirin, NSAIDs, antiplatelet agents, anticoagulants and SSRIs.

Lyophilized powder for IV solution (requires reconstitution): 500 units/single-use vial

IV (Adults ): Initial dose: 200 units/kg; further doses every 4–12 hr are titrated and based on clinical response and factor VIII recovery levels.

Obizur

Therapeutic effects:

Therapeutic Classification: hemostatic agents, none assigned

Pharmacologic Classification: clotting factors replacements

Vary from patient to patient

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Used up in the hemostatic process.

Half-Life: Unknown.

(effect on factor VIII levels)

ROUTE	ONSET	PEAK	DURATION
IV	rapid	30 min	4–12 hr

Explain rationale for medication to patient.
Instruct patient to notify health care professional of adverse reactions or problems following administration.
Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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