• Acute coronary syndrome (ST-segment elevation MI, non-ST-segment elevation MI, or unstable angina).
• Patients with established peripheral arterial disease, recent MI, or recent stroke.

Contraindicated in:

• Hypersensitivity to clopidogrel or prasugrel
• Pathologic bleeding (peptic ulcer, intracranial hemorrhage)
• Concurrent use of omeprazole or esomeprazole
• CYP2C19 poor metabolizers.

Use Cautiously in:

• Patients at risk for bleeding (trauma, surgery, or other pathologic conditions)
• History of GI bleeding/ulcer disease
• Severe hepatic impairment
• Hypersensitivity to another thienopyridine (prasugrel)
• OB: Use should not be withheld, if needed for emergent treatment of stroke or MI during pregnancy. Discontinue use 5 to 7 days prior to labor, delivery, or neuraxial blockade, if possible, due to ↑ risk of maternal bleeding and hemorrhage
• Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant
• Pedi: Safety and effectiveness not established in children.

CV: chest pain, edema, hypertension.

Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS, pruritus, purpura, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.

EENT: epistaxis.

GI: abdominal pain, diarrhea, dyspepsia, gastritis, GI BLEEDING.

Hemat: BLEEDING, NEUTROPENIA, THROMBOTIC THROMBOCYTOPENIC PURPURA.

Metab: hypercholesterolemia.

MS: arthralgia, back pain.

Neuro: depression, dizziness, fatigue, headache.

Resp: cough, dyspnea, eosinophilic pneumonia.
Misc: fever, (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS .

Drug-Drug:

• Concurrent eptifibatide, tirofiban, aspirin, dipyridamole, NSAIDs, heparin, LMWHs, thrombolytic agents, SSRIs, SNRIs, or warfarin may ↑ risk of bleeding.
• Strong CYP2C19 inducers, including rifampin, may ↑ risk of bleeding; avoid concurrent use.
• May ↓ metabolism and ↑ effects of phenytoin, repaglinide, tamoxifen, torsemide, fluvastatin, and many NSAIDs; avoid concurrent use with repaglinide.
• Concurrent use with the CYP2C19 inhibitors, omeprazole, or esomeprazole may ↓ antiplatelet effects; avoid concurrent use; may consider using H₂ antagonist or pantoprazole.
• Opioids may ↓ absorption of clopidogrel and its active metabolite and ↓ antiplatelet effects; consider using parenteral antiplatelet in patients with acute coronary syndrome if concurrent use of opioids needed.

Drug-Natural Products:

• ↑bleeding risk with anise, arnica, chamomile, clove, fenugreek, feverfew, garlic, ginger, ginkgo, Panax ginseng, and others.

(Generic available)

• Tablets: 75 mg; 300 mg;

Recent MI, Stroke, or Peripheral Arterial Disease

• PO (Adults): 75 mg once daily.

Acute Coronary Syndrome

• PO (Adults): 300 mg initially, then 75 mg once daily; aspirin 75–325 mg once daily should be given concurrently.

Plavix

• Inhibits platelet aggregation by irreversibly inhibiting the binding of ATP to platelet receptors.

• Reduction in risk of MI and stroke.

Therapeutic Classification: antiplatelet agents

Pharmacologic Classification: platelet aggregation inhibitors

Absorption: Well absorbed following oral administration; rapidly metabolized to an active antiplatelet compound. Parent drug has no antiplatelet activity.

Distribution: Unknown.

Protein Binding: Clopidogrel: 98%; active metabolite: 94%.

Metabolism/Excretion: Rapidly and extensively converted by the liver via the CYP2C19 isoenzyme to its active metabolite, which is then eliminated 50% in urine and 45% in feces;2% of Whites, 4% of Blacks, and 14% of Asians have CYP2C19 genotype that results in reduced metabolism of clopidogrel (poor metabolizers) into its active metabolite (may result in ↓ antiplatelet effects).

Half-life: 6 hr (active metabolite 30 min).

(effects on platelet function)

†Following discontinuation.

• Instruct patient to take medication exactly as directed. Take missed doses as soon as possible unless almost time for next dose; do not double doses. Do not discontinue clopidogrel without consulting health care professional; may increase risk of cardiovascular events. Advise patient to read the Medication Guide before starting clopidogrel and with each Rx refill in case of changes.
• Advise patient to notify health care professional promptly if signs and symptoms of bleeding (unexpected bleeding or bleeding that lasts a long time; blood in urine [pink, red, or brown urine], red or black stools [looks like tar], bruises without known cause or get larger; cough up blood or blood clots; vomit blood or vomit looks like coffee grounds); fever, weakness, chills, sore throat, rash, unusual bleeding or bruising, extreme skin paleness, purple skin patches, yellowing of skin or eyes, or neurological changes occur.
• Advise patient to notify health care professional of medication regimen prior to treatment or surgery.
• Caution patient to avoid taking omeprazole or esomeprazole during therapy. Consult health care professional for other options.
• Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking any other Rx, OTC, or herbal products, especially those containing aspirin or NSAIDs or proton pump inhibitors.
• Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected, or if breastfeeding. Therapy should not be withheld because of potential concerns regarding effects of clopidogrel on the fetus. Use during labor or delivery increases risk of maternal bleeding and hemorrhage. Avoid neuraxial blockade during clopidogrel use due to risk of spinal hematoma. When possible, discontinue clopidogrel 5 to 7 days prior to labor, delivery, or neuraxial blockade.

kloh-PID-oh-grel