section name header

Indications

High Alert

Anesthesia adjunct:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: ARRHYTHMIAS, bradycardia, chest pain, hypertension, ischemia, tachycardia.

Derm: pruritus.

GI: epigastric pain, nausea, vomiting.

Local: phlebitis, sloughing at IV sites.

Neuro: blurred vision, headache, insomnia, nervousness, tremor.

Resp: dyspnea.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Hypotension

Hypotension During Anesthesia

Vasoconstrictor for Regional Anesthesia

Prolongation of Spinal Anesthesia

US Brand Names

Biorphen, Vazculep

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: vasopressors

Pharmacologic Classification: adrenergics, vasopressors

Pharmacokinetics

Absorption: Well absorbed from IM sites. IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Metabolized by the liver into inactive metabolites.

Half-life: 2.5 hr.

Canadian Brand Names

Neo-Synephrine

Time/Action Profile

(vasopressor effects)

ROUTEONSETPEAKDURATION
IVimmediateunknown15–20 min
IM10–15 minunknown0.5–2 hr
SUBQ10–15 minunknown50–60 min

Patient/Family Teaching

Pronunciation

fen-il-EFF-rin