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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension, tachycardia.

Derm: erythema, flushing, urticaria.

EENT: blurred vision, cataracts, ototoxicity.

GI: abdominal pain, diarrhea.

GU: red urine.

Local: induration at injection site, pain at injection site.

MS: leg cramps.
Misc: fever, (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS , shock (after rapid IV administration).

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Acute Iron Ingestion

Chronic Iron Overload

US Brand Names

Desferal

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antidotes

Pharmacologic Classification: heavy metal antagonists

Pharmacokinetics

Absorption: Poorly absorbed after oral administration. Well absorbed after IM administration and SUBQ administration. IV administration results in complete bioavailability.

Distribution: Appears to be widely distributed.

Metabolism/Excretion: Metabolized by tissues and plasma enzymes. Unchanged drug and chelated form excreted by the kidneys; 33% of iron removed is eliminated in the feces via biliary excretion.

Half-life: 1 hr.

Time/Action Profile

(effects on hematologic parameters)

ROUTEONSETPEAKDURATION
IVrapidunknownunknown
IMunknownunknownunknown
SUBQunknownunknownunknown

Patient/Family Teaching

Pronunciation

de-fer-OX-a-meen