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Indications

REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension.

Derm: necrolytic migratory erythema.

EENT: epistaxis, eye redness, itchy eyes, itchy throat, nasal congestion, nasal discomfort, nasal itching, rhinorrhea, sneezing, watery eyes.

GI: nausea, vomiting.

Neuro: headache.

Resp: cough.
Misc: (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Hypoglycemia

Radiographic Examination of the GI Tract

Beta Blocker or Calcium Channel Blocker Overdose

US Brand Names

Baqsimi, GlucaGen, Gvoke

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: hormones

Pharmacologic Classification: pancreatics

Pharmacokinetics

Absorption: Well absorbed following IM, intranasal, and SUBQ administration; IV administration results in complete bioavailability.

Distribution: Extensively distributed to tissues.

Metabolism/Excretion: Extensively metabolized by the liver, plasma, and kidneys.

Half-life: 8–18 min.

Time/Action Profile

ROUTEONSETPEAKDURATION
IM (hyperglycemic action)within 10 min30 min12–27 min
IV (hyperglycemic action)1 min5 min9–17 min
SUBQ (hyperglycemic action)within 10 min30–45 min60–90 min
Intranasal (hyperglycemic action)within 15 minunknownunknown
IV (effect on GI musculature)45 sec (for 0.25–2-mg dose)unknown9–17 min (0.25–0.5-mg dose); 22–25 min (2-mg dose)
IM (effect on GI musculature)8–10 min (1-mg dose); 4–7 min (2-mg dose)unknown9–27 min (1-mg dose); 21–32 min (2-mg dose)

Patient/Family Teaching

Pronunciation

GLOO-ka-gon