section name header

Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: rash.

Endo: Graves' disease.

GI: diarrhea, abdominal pain, autoimmune hepatitis, hyperbilirubinemia, lipase, liver enzymes, nausea.

GU: serum creatinine.

MS: creatine kinase, polymyositis.

Neuro: abnormal dreams, dizziness, fatigue, Guillain-Barré syndrome, headache, insomnia, sedation.
Misc: immune reconstitution syndrome.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

Route/Dosage

US Brand Names

Pifeltro

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: non nucleoside reverse transcriptase inhibitors

Pharmacokinetics

Absorption: 64% absorbed following oral administration.

Distribution: Extensively distributed to tissues.

Metabolism/Excretion: Primarily metabolized in the liver by the CYP3A enzymes. Primarily excreted in feces (as metabolites), 6% unchanged in urine.

Half-life: 15 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown2 hr24 hr

Patient/Family Teaching

Pronunciation

DOR-a-VIR-een