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Indications

High Alert


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: alopecia

GI: abdominal pain, diarrhea, nausea, vomiting, liver enzymes, anorexia, constipation, stomatitis

Hemat: anemia, leukopenia, thrombocytopenia

MS: arthralgia

Neuro: headache, fatigue, weakness

Resp: dyspnea, ILD

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

Renal Impairment

Renal Impairment

US Brand Names

Hycamtin

Action

  • Interferes with DNA synthesis by inhibiting the enzyme topoisomerase.
Therapeutic effects:
  • Death of rapidly replicating cells, particularly malignant ones.

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: enzyme inhibitors

Pharmacokinetics

Absorption: IV administration results in complete bioavailability. 40% absorbed following oral administration.

Distribution: Well distributed to tissues.

Metabolism/Excretion: Small amounts metabolized by the liver. 18–33% excreted in feces and 20–50% excreted in urine (primarily as metabolites).

Half-Life: PO: 3–6 hr; IV: 2–3 hr.

Time/Action Profile

(effects on WBCs)

ROUTEONSETPEAKDURATION
POunknown1–2 hr24 hr
IVwithin days11 days7 days



Patient/Family Teaching

Pronunciation

toe-poe-TEE-kan