section name header

Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema, hypertension, venous thromboembolism.

Derm: rash, abnormal wound healing.

EENT: conjunctivitis.

Endo: hyperglycemia.

F and E: edema, hypophosphatemia.

GI: liver enzymes, anorexia, diarrhea, mucositis, nausea, BOWEL PERFORATION .

GU: nephrotic syndrome, proteinuria, RENAL FAILURE.

Hemat: anemia, leukopenia, lymphopenia, thrombocytopenia.

Metab: hyperlipidemia, hypertriglyceridemia.

Neuro: weakness.

Resp: INTERSTITIAL LUNG DISEASE.
Misc: (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS , INFECTION.

Interactions

Drug-Drug:

Drug-Natural Products:

Drug-Food:

Availability

(Generic available)

Route/Dosage

US Brand Names

Torisel

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: enzyme inhibitors, kinase inhibitors

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Temsirolimus and sirolimus partition extensively in formed blood elements.

Metabolism/Excretion: Mostly metabolized by the liver to sirolimus, an active metabolite Primarily eliminated in feces.

Half-life: Temsirolimus: 17.3 hr; sirolimus: 54.6 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
IVunknownend of infusion1 wk

Patient/Family Teaching

Pronunciation

tem-si-RO-li-mus