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Indications

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension

Derm: rash

GI: nausea, vomiting, diarrhea, heartburn, decreased appetite

Neuro: dizziness

Interactions

Natural-Drug Products:

Natural-Natural Products:

Availability

Route/Dosage

US Brand Names

coQ10, ubiquinol, ubiquinone

Action

  • A cofactor in oxidative respiration for the Krebs cycle and the electron transport chain important for mitochondrial ATP generation. It also has antioxidant activity and membrane stabilizing ability.
Therapeutic effects:
  • Antioxidant effects.

Classifications

Therapeutic Classification: antioxidants

Pharmacokinetics

Absorption: Poor absorption in the GI tract, absorbed primarily in the small intestine.

Distribution: Unknown.

Metabolism/Excretion: Metabolized in all tissues, elimination via biliary and fecal excretion.

Half-Life: 34 hr.

Time/Action Profile

ONSETPEAKDURATION
POUnknown5–10 hrUnknown

Patient/Family Teaching

Pronunciation

ko-EN-zime-cue-ten