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Indications

BEERS REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: syncope.

Derm: blister, pruritus.

Hemat: BLEEDING.

Local: wound secretion.

MS: extremity pain, muscle spasm.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

Route/Dosage

Prevention of Deep Vein Thrombosis Following Knee or Hip Replacement Surgery

Prevention of Venous Thromboembolism in Acutely Ill Medical Patients at Risk for Thromboembolic Complications Not at High Risk of Bleeding

Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Reduction in Risk of Recurrent Deep Vein Thrombosis and/or Pulmonary Embolism in Patients at Continued Risk for Recurrent Deep Vein Thrombosis and/or Pulmonary Embolism

Reduction in Risk of Stroke/Systemic Embolism in Nonvalvular Atrial Fibrillation

Renal Impairment

Reduction in Risk of Major Cardiovascular Events in Patients With Chronic Coronary Artery Disease or Reduction in Risk of Major Thrombotic Vascular Events in Peripheral Arterial Disease, Including Patients After Lower Extremity Revascularization Due to Symptomatic Peripheral Arterial Disease

Treatment of Venous Thromboembolism and Reduction in Risk of Recurrent Venous Thromboembolism in Pediatric Patients

Thromboprophylaxis in Pediatric Patients With Congenital Heart Disease After Fontan Procedure

US Brand Names

Xarelto

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: anticoagulants

Pharmacologic Classification: antithrombotics

Pharmacokinetics

Absorption: Well absorbed (80%) following oral administration; absorption occurs in the stomach and as it enters the small intestine.

Distribution: Unknown.

Metabolism/Excretion: 51% metabolized by the liver; 36% excreted unchanged in urine. Metabolites do not have anticoagulant activity.

Half-life: 5–9 hr.

Time/Action Profile

(anticoagulant effect)

ROUTEONSETPEAKDURATION
POunknown2–4 hr24 hr

†Plasma concentrations.

Patient/Family Teaching

Pronunciation

ri-va-ROX-a-ban