clotrimazole (topical)

REMS

Various cutaneous fungal infections, including cutaneous candidiasis, tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor.

Contraind./Precautions

⬆ ⬇

Contraindicated in:

Hypersensitivity to active ingredients, additives, preservatives, or bases.

Use Cautiously in:

Nail and scalp infections (may require additional systemic therapy);

Adv. Reactions/Side Effects

⬆ ⬇

Local: burning, itching, local hypersensitivity reactions, redness, stinging

Interactions

⬆ ⬇

Drug-drug:

None reported.

Availability

⬆ ⬇

(Generic available)

Cream: 1%^OTC
Lotion: 1%^OTC
Ointment: 1%^OTC
Solution: 1%^OTC
In combination with: betamethasone.

Route/Dosage

⬆ ⬇

(Adults and Children >3 yr): Apply cream or solution twice daily for 1–4 wk.

US Brand Names

⬆ ⬇

Alevazol, Votriza-AL

Action

⬆ ⬇

Affects the permeability of the fungal cell wall, allowing leakage of cellular contents.

Therapeutic effects:

Decrease in symptoms of fungal infection.

Classifications

⬆ ⬇

Therapeutic Classification: antifungals (topical)

Pharmacokinetics

⬆ ⬇

Absorption: Absorption through intact skin is minimal.

Distribution: Distribution after topical administration is primarily local.

Metabolism/Excretion: Systemic metabolism and excretion is negligible with local application.

Half-Life: Not applicable.

Canadian Brand Names

⬆ ⬇

Canesten, Clotrimaderm

Time/Action Profile

⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
Top	unknown	unknown	unknown

Patient/Family Teaching

⬆ ⬇

Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes.
Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream can usually be cleaned by handwashing with soap and warm water.
Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
Advise patient to report increased skin irritation or lack of response to therapy to health care professional.
Inform patient that early relief of symptoms may be seen in 2–3 days. For Candida, tinea cruris, and tinea corporis, 2 wk are needed, and for tinea pedis, therapeutic response may take 3–4 wk. Recurrent fungal infections may be a sign of systemic illness.

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Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆

Indications