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Indications

High Alert

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Noted for patients receiving heparin and aspirin in addition to tirofiban

CV: bradycardia, coronary dissection, edema, vasovagal reaction.

Derm: hives, rash, sweating.

GI: nausea.

Hemat: BLEEDING, thrombocytopenia.

MS: leg pain.

Neuro: headache, dizziness.
Misc: fever, (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS , pelvic pain.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

see Calculator

Renal Impairment

US Brand Names

Aggrastat

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiplatelet agents

Pharmacologic Classification: glycoprotein iib iiia inhibitors

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Excreted mostly unchanged by the kidneys (65%); 25% excreted unchanged in feces.

Half-life: 2 hr.

Time/Action Profile

(effects on platelet function)

ROUTEONSETPEAKDURATION
IVrapid30 minbrief

†>90% inhibition of platelet aggregation at end of initial 30-min infusion.

†Inhibition is reversible following cessation of infusion.

Patient/Family Teaching

Pronunciation

tye-roe-FYE-ban