section name header

Indications

High Alert


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

Reduction in Risk of Stroke/Systemic Embolism in Nonvalvular Atrial Fibrillation

Renal Impairment

Prevention of Deep Vein Thrombosis Following Knee or Hip Replacement Surgery

Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Reduction in Risk of Recurrence of Deep Vein Thrombosis or Pulmonary Embolism

US Brand Names

Eliquis

Action

  • Acts as a selective, reversible site inhibitor of factor Xa, inhibiting both free and bound factor. Does not affect platelet aggregation directly, but does inhibit thrombin-induced platelet aggregation. Decreases thrombin generation and thrombus development.
Therapeutic effects:
  • Treatment and prevention of thromboembolic events.

Classifications

Therapeutic Classification: anticoagulants

Pharmacologic Classification: factor xa inhibitors

Pharmacokinetics

Absorption: 50% absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized by the liver by the CYP3A4 isoenzyme; excreted in urine and feces. Biliary and direct intestinal excretion account for fecal elimination.

Half-Life: 6 hr (12 hr after repeated dosing due to prolonged absorption).

Time/Action Profile

(effect on hemostasis)

ROUTEONSETPEAKDURATION
POunknown3–4 hr24 hr

Blood levels.



Patient/Family Teaching

Pronunciation

a-PIX-a-ban