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Indications

High Alert


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Drug-Natural Products:

Drug-Food:

Availability

(Generic available)

Route/Dosage

Hepatic Impairment

US Brand Names

Torisel

Action

  • Binds to an intracellular protein. The resultant complex inhibits an enzyme, mTOR (mammalian target of rapamycin). Inhibition of this enzyme arrests cell growth in the G1 phase.
Therapeutic effects:
  • Decreased spread of renal cell carcinoma.

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: enzyme inhibitors, kinase inhibitors

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Temsirolimus and sirolimus partition extensively in formed blood elements.

Metabolism/Excretion: Mostly metabolized by the liver to sirolimus, an active metabolite. Primarily eliminated in feces.

Half-Life: Temsirolimus: 17.3 hr; sirolimus: 54.6 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
IVunknownend of infusion1 wk



Patient/Family Teaching

Pronunciation

tem-si-RO-li-mus