glycopyrronium

Contraindicated in:

Glaucoma;
Acute hemorrhage;
Severe ulcerative colitis;
Toxic megacolon;
Myasthenia gravis;
Sjögren syndrome;
Paralytic ileus

Use Cautiously in:

Prostatic hypertrophy or bladder-neck obstruction;
Renal impairment;
OB: Safety not established in pregnancy;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Children <9 yr (safety and effectiveness not established).

Adv. Reactions/Side Effects ⬆ ⬇

Derm: burning, erythema, dry skin, pruritus

EENT: blurred vision, dry eye, mydriasis, nasal dryness, oropharyngeal pain

GI: dry mouth, constipation

GU: urinary hesitation, urinary retention

Neuro: headache

Misc: fever, heat stroke

Interactions ⬆ ⬇

Drug-drug:

Additive anticholinergic effects with other anticholinergics, including antihistamines, phenothiazines, meperidine, amantadine, tricyclic antidepressants, quinidine, and disopyramide; avoid concurrent use.

Availability ⬆ ⬇

Topical cloths: 2.4%

Route/Dosage ⬆ ⬇

(Adults and Children ≥9 yr): Using a single cloth, apply to each underarm not more frequently than once every 24 hr.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Inhibits the action of acetylcholine at receptors on certain peripheral tissues, including sweat glands, which reduces sweating.

Therapeutic effects:

Reduced sweating.

Classifications ⬆ ⬇

Therapeutic Classification: none assigned

Pharmacologic Classification: anticholinergics

Pharmacokinetics ⬆ ⬇

Absorption: Not systemically absorbed after topical administration.

Distribution: Minimal to no distribution to tissues.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
Topical	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Instruct patient in correct technique for applications. Do not apply to areas other than the underarm. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes.
Advise patient to discard the cloth after using it in the household trash out of reach of children. Advise patient to wash their hands thoroughly with soap and water after applying and discarding the cloth.
Do not apply to broken skin or use with occlusive dressings.
May cause transient blurred vision. Caution patient to avoid driving and other activities requiring clear vision until response to medication is known.
Advise patients to watch for generalized lack of sweating when in hot or very warm temperatures and to avoid use if not sweating under these conditions. If signs and symptoms of heat illness (hot, red skin; decreased alertness or passing out; fast, weak pulse; fast, shallow breathing; fever) occur, notify health care professional promptly.
Advise patient to notify health care professional immediately if signs and symptoms of urinary retention (difficulty urinating, urinating frequently, urination in a weak stream or drips, full bladder, difficulty emptying bladder) occur.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Indications ⬇

Contraind./Precautions ⬆ ⬇