REMS
Contraindicated in:
Use Cautiously in:
CV: tachycardia, hypotension, palpitations
Derm: alopecia, ERYTHEMA MULTIFORME, oligohydrosis (↓ sweating), STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS
EENT: acute myopia, blurred vision, eye pain, secondary angle closure glaucoma, visual field defects
Endo: hypoglycemia
F and E: hypokalemia, metabolic acidosis
GI: altered taste, constipation, dry mouth, HEPATOTOXICITY
GU: ↑serum creatinine, kidney stones
Neuro: headache, insomnia, paresthesia, cognitive impairment, dizziness, mood disorders, SEIZURES (FOLLOWING ABRUPT DISCONTINUATION), SUICIDAL IDEATION
Misc: ALLERGIC REACTION, hyperthermia
Drug-drug:
Renal Impairment
Hepatic Impairment
Therapeutic Classification: weight control agents
Pharmacologic Classification: appetite suppressants
Phentermine
Absorption: Extent of absorption following oral administration unknown.
Distribution: Unknown.
Half-Life: 1924 hr.
Topiramate
Absorption: 80% absorbed following oral administration.
Distribution: Unknown
Half-Life: 21 hr.