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Indications

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

GI: diarrhea, flatulence, vomiting

Neuro: agitation, dizziness, manic reactions (in patients with bipolar disorder), mild insomnia

Interactions

Natural-Drug Products:

Natural-Natural Products:

Availability

Route/Dosage

US Brand Names

Ademetionine, S-adenosylmethionine

Action

  • May aid in the production, activation, and metabolism of various amines, phospholipids, hormones, and neurotransmitters. May stimulate articular cartilage growth and repair.
Therapeutic effects:
  • Decreased depression.
  • Anti-inflammatory and analgesic effects improve symptoms of osteoarthritis.

Classifications

Therapeutic Classification: antidepressants

Pharmacokinetics

Absorption: Rapidly and extensively metabolized following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Actively metabolized by the liver.

Half-Life: 100 min.

Time/Action Profile

(antidepressant action)

ROUTEONSETPEAKDURATION
PO (depression)1–2 wkunknownunknown
PO (osteoarthritis)30 daysunknownunknown

Patient/Family Teaching

Pronunciation

SAM-ee