soy

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Indications ⬇

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

REMS

Menopausal symptoms.
Prevention of breast, lung, endometrial, thyroid and prostate cancers.
Hyperlipidemia.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity.
End stage renal disease.
Urinary bladder cancer (may increase risk).

Use Cautiously in:

Nephrolithiasis.
Hypothyroidism.

Adv. Reactions/Side Effects ⬆ ⬇

CV: insomnia

GI: bloating, constipation, gastrointestinal upset

Interactions ⬆ ⬇

Natural-Drug Products:

Antibiotics may ↓ effects of soy.
May inhibit effects of estrogensand tamoxifen.
May ↑ risk of hypertensive crisis with MAO inhibitors.
May ↓ INR of patients taking warfarin..

Natural-Natural Products:

None.

Availability ⬆ ⬇

Tablets: Powder

Route/Dosage ⬆ ⬇

PO (Adults ): 35–120 mg/day.

US Brand Names ⬆ ⬇

glycine max, soy protein, isoflavone

Action ⬆ ⬇

Soy is the most significant dietary source of isoflavones. Pharmacologic effects of soy include lowering of homocysteine levels, inhibition of platelet aggregation, lowering of BP, inhibition of cholesterol absorption in the small bowel and lowering of LDL cholesterol. Soy isoflavones also have antioxidant, antiproliferative and estrogenic effects.

Therapeutic effects:

Decreased cholesterol.
Decreased hot flashes in menopausal women.

Classifications ⬆ ⬇

Therapeutic Classification: antioxidants, caloric sources

Pharmacokinetics ⬆ ⬇

Absorption: Unknown

Distribution: Unknown

Metabolism/Excretion: Unknown

Half-Life: Unknown

Time/Action Profile ⬆ ⬇

	ONSET	PEAK	DURATION
PO	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Instruct patient to take as directed.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.

Pronunciation ⬆

SOI