section name header

Indications

REMS

Viagra:

Revatio and Liqrev:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension, MI, SUDDEN DEATH, vaso-occlusive crises.

Derm: flushing, rash.

EENT: epistaxis, hearing loss, nasal congestion, vision loss.

GI: dyspepsia, diarrhea.

GU: priapism, urinary tract infection.

MS: myalgia.

Neuro: headache, dizziness, insomnia, paresthesia.
Misc: (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Erectile Dysfunction

Hepatic Impairment

Pulmonary Arterial Hypertension

IV therapy is indicated for patients unable to take PO therapy

US Brand Names

Liqrev, Revatio, Viagra

Action

Therapeutic Effects:

Classifications

Therapeutic Classification:erectile dysfunction agents, vasodilators

Pharmacologic Classification: phosphodiesterase type 5 inhibitors

Pharmacokinetics

Absorption: Rapidly absorbed (41%) after oral administration; IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues; negligible amount in semen.

Protein Binding: 96%.

Metabolism/Excretion: Primarily metabolized by the liver via the CYP3A4 isoenzyme; one metabolite is active and accounts for 20% or more of drug effect. Metabolites excreted mostly (80%) in feces; 13% excreted in urine.

Half-life: 4 hr (for sildenafil and active metabolite).

Time/Action Profile

(vasodilation, ability to produce erection)

ROUTEONSETPEAKDURATION
POwithin 1 hr30–120 minup to 4 hr

Patient/Family Teaching

Pronunciation

sil-DEN-a-fil

Pill Image

sildenafil_9192.jpg