tenofovir disoproxil fumarate

Contraindicated in:

Hypersensitivity;
Concurrent use of antiretroviral combination products containing tenofovir;
Concurrent or recent use of NSAIDs (↑ risk of acute renal failure);
Lactation: Breastfeeding not recommended in women with HIV.

Use Cautiously in:

Coinfection with HIV and chronic HBV (HBV may exacerbate following discontinuation);
Obesity, women, prolonged nucleoside exposure (may be risk factors for lactic acidosis/hepatomegaly);
Renal impairment (↑ dosing interval if CCr <50 mL/min);
History of pathologic bone fractures or at risk for osteopenia;
Pedi: Children <2 yr (safety and effectiveness not established).

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash

F and E: hypophosphatemia

GI: diarrhea, nausea, abdominal pain, anorexia, flatulence, LACTIC ACIDOSIS/HEPATOMEGALY WITH STEATOSIS, vomiting

GU: ACUTE RENAL FAILURE/FANCONI SYNDROME, proximal renal tubulopathy, renal impairment

MS: ↓bone mineral density, bone pain, muscle pain, osteomalacia

Neuro: depression, headache, weakness

Misc: immune reconstitution syndrome

Interactions ⬆ ⬇

Drug-drug:

Cidofovir, acyclovir, ganciclovir, or valganciclovir may ↑ levels and risk of toxicity.
Risk of renal toxicity ↑ by other nephrotoxic agents.
Combination therapy with atazanavir may lead to ↓ virologic response and possible resistance to atazanavir (small amounts of ritonavir may be added to boost atazanavir levels); may also ↑ tenofovir levels.
Lopinavir/ritonavir, ledipasvir/sofosbuvir, sofosbuvir/velpatasvir, and sofosbuvir/velpatasvir/voxilaprevir may ↑ levels and risk of toxicity.
Concurrent use with adefovir for chronic hepatitis B infection should be avoided.
Concurrent use with NSAIDs may ↑ risk of acute renal failure.

Availability ⬆ ⬇

(Generic available)

Oral powder: 40 mg/scoop
Tablets: 150 mg; 200 mg; 250 mg; 300 mg
In combination with: doravirine and lamivudine (Delstrigo); efavirenz and emtricitabine (Atripla); efavirenz and lamivudine (Symfi, Symfi Lo); cobicistat and emtricitabine (Stribild); emtricitabine (Truvada); emtricitabine and rilpivirine (Complera); lamivudine (Cimduo). See Appendix [not included in this PDA edition].

Route/Dosage ⬆ ⬇

PO (Adults and Children ≥2 yr and ≥35 kg): 300 mg once daily.
PO (Children ≥2 yr and 17–34.9 kg): Tablets:28–34.9 kg: 250 mg once daily; 22–27.9 kg: 200 mg once daily; 17–21.9 kg: 150 mg once daily.
PO (Children ≥2 yr and 10–34.9 kg): Oral Powder:34–34.9 kg: 7 scoops (280 mg) once daily; 32–33.9 kg: 6.5 scoops (260 mg) once daily; 29–31.9 kg: 6 scoops (240 mg) once daily; 27–28.9 kg: 5.5 scoops (220 mg) once daily; 24–26.9 kg: 5 scoops (200 mg) once daily; 22–23.9 kg: 4.5 scoops (180 mg) once daily; 19–21.9 kg: 4 scoops (160 mg) once daily; 17–18.9 kg: 3.5 scoops (140 mg) once daily; 14–16.9 kg: 3 scoops (120 mg) once daily; 12–13.9 kg: 2.5 scoops (100 mg) once daily; 10–11.9 kg: 2 scoops (80 mg) once daily.

Renal Impairment

PO (Adults ): CCr 30–49 mL/min: 300 mg every 48 hr; CCr 10–29 mL/min: 300 mg every 72–96 hr; Hemodialysis: 300 mg every 7 days following dialysis.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Active drug (tenofovir) is phosphorylated intracellularly; tenofovir diphosphate inhibits HIV reverse transcriptase resulting in disruption of DNA synthesis.

Therapeutic effects:

Slowed progression of HIV infection and decreased occurrence of sequelae.
Increased CD4 cell count and decreased viral load.
Decreased progression/sequelae of chronic HBV infection.

Classifications ⬆ ⬇

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: nucleoside reverse transcriptase inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: Tenofovir disoproxil fumarate is a prodrug, which is split into tenofovir, the active component. Absorption ↑ by food.

Distribution: Minimally distributed to extravascular tissues.

Metabolism/Excretion: 70–80% excreted unchanged in urine by glomerular filtration and active tubular secretion.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	2 hr*	24 hr

*When taken with food.

Patient/Family Teaching ⬆ ⬇

Instruct patient on the importance of taking tenofovir disoproxil fumarate as directed, even if feeling better. Do not take more than prescribed amount and do not stop taking without consulting health care professional. Discontinuing therapy may lead to severe exacerbations. Take missed doses as soon as remembered unless almost time for next dose; do not double doses. Caution patient not to share or trade this medication with others.
Inform patient that tenofovir may cause hyperglycemia. Advise patient to notify health care professional if ↑ thirst or hunger; unexplained weight loss; ↑ urination; fatigue; or dry, itchy skin occurs.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
Caution patient to avoid crowds and persons with known infections.
Inform patient that tenofovir disoproxil fumarate does not cure HIV and may ↓ the risk of transmission of HIV to others through sexual contact or blood contamination. Caution patient to use a condom and avoid sharing needles or donating blood to prevent spreading HIV to others.
Advise patient to notify health care professional immediately if symptoms of lactic acidosis (nausea, vomiting, unusual or unexpected stomach discomfort, weakness) or signs of immune reconstitution syndrome (signs and symptoms of an infection) occur.
Rep: Advise women of reproductive potential taking oral contraceptives to use a nonhormonal method of birth control during tenofovir disoproxil fumarate therapy. If pregnancy is suspected, notify health care professional promptly. Encourage pregnant women to enroll in the Antiretroviral Pregnancy Registry by calling 1-800-258-4263. Advise females to avoid breastfeeding during therapy.

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Indications ⬇

Contraind./Precautions ⬆ ⬇