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Indications

BEERS REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: first-dose orthostatic hypotension, palpitations, angina, edema, syncope.

EENT: blurred vision, intraoperative floppy iris syndrome.

GI: abdominal cramps, diarrhea, dry mouth, nausea, vomiting.

GU: erectile dysfunction, priapism.

Neuro: dizziness, headache, weakness, depression, drowsiness.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Hypertension

Benign Prostatic Hyperplasia

US Brand Names

Minipress

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: peripherally acting antiadrenergics

Pharmacokinetics

Absorption: 60% absorbed following oral administration.

Distribution: Widely distributed.

Protein Binding: 97%.

Metabolism/Excretion: Extensively metabolized by the liver. Minimal (5–10%) renal excretion of unchanged drug.

Half-life: 2–3 hr.

Time/Action Profile

(antihypertensive effects)

ROUTEONSETPEAKDURATION
PO2 hr2–4 hr10 hr

†Following single dose; maximal antihypertensive effects occur after 3–4 wk of chronic dosing.

Patient/Family Teaching

Pronunciation

PRA-zoe-sin