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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Drug-Food:

Availability

(Generic available)

Route/Dosage

Hepatic Impairment

US Brand Names

Sular

Action

  • Inhibits the transport of calcium into vascular smooth muscle cells, resulting in inhibition of vasoconstriction and dilation of arterioles.
Therapeutic effects:
  • Systemic vasodilation, resulting in BP.

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: calcium channel blockers

Pharmacokinetics

Absorption: Well absorbed (87%) following oral administration but rapidly and extensively metabolized in the gut wall, resulting in 5% bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized in the liver via the CYP3A4 isoenzyme.

Half-Life: 7–12 hr.

Time/Action Profile

(antihypertensive effects)

ROUTEONSETPEAKDURATION
POunknown6–12 hr24 hr



Patient/Family Teaching

Pronunciation

nye-SOLE-di-peen