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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: STEVENS-JOHNSON SYNDROME, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), hirsutism, rash, urticaria.

EENT: myopia.

GI: abdominal pain, anorexia, cramping, diarrhea, hiccups, nausea, vomiting, weight loss.

GU: pink/brown discoloration of urine, vaginal bleeding.

Hemat: agranulocytosis, eosinophilia, immune thrombocytopenia, leukopenia, pancytopenia.

Neuro: FREQUENCY OF TONIC-CLONIC (GRAND MAL) SEIZURES, SUICIDAL THOUGHTS, ataxia, dizziness, drowsiness, euphoria, fatigue, headache, hyperactivity, irritability, psychiatric disturbances.
Misc: ALLERGIC REACTION, systemic lupus erythematosus.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

see Calculator

US Brand Names

Zarontin

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: anticonvulsants

Pharmacokinetics

Absorption: Rapidly and completely absorbed from the GI tract following oral administration.

Distribution: Freely distributed throughout body water.

Metabolism/Excretion: Mostly metabolized by the liver. 10% excreted unchanged by the kidneys.

Half-life: 50–60 hr (adults); 30 hr (children).

Time/Action Profile

(anticonvulsant activity)

ROUTEONSETPEAKDURATION
POhr–daysdaysdays

Patient/Family Teaching

Pronunciation

eth-oh-SUX-i-mide