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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension.

EENT: sinusitis.

F and E: hyperkalemia.

GI: abdominal pain, diarrhea, dyspepsia.

GU: renal impairment.

MS: back pain, myalgia.

Neuro: dizziness, fatigue, headache.
Misc: ANGIOEDEMA.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Hypertension

Cardiovascular Risk Reduction

US Brand Names

Micardis

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: angiotensin II receptor antagonists

Pharmacokinetics

Absorption: 42–58% absorbed following oral administration (bioavailability increased in patients with hepatic impairment).

Distribution: Crosses the placenta.

Protein Binding: 99.5%.

Metabolism/Excretion: Excreted mostly unchanged in feces via biliary excretion.

Half-life: 24 hr.

Time/Action Profile

(antihypertensive effect)

ROUTEONSETPEAKDURATION
POwithin 3 hr*4 wk24 hr

*After single dose.

†Chronic dosing.

Patient/Family Teaching

Pronunciation

tel-mi-SAR-tan