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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME

GI: diarrhea, dyspepsia, dysphagia, ESOPHAGEAL CANCER, esophageal/gastric ulcer, esophagitis

Local: injection site reactions

MS: musculoskeletal pain, pain in arms/legs, femur fractures, osteonecrosis (primarily of jaw)

Resp: asthma exacerbation

Misc: ANAPHYLAXIS

Interactions

Drug-drug:

Drug-Food:

Availability

(Generic available)

Route/Dosage

US Brand Names

Boniva

Action

  • Inhibits resorption of bone by inhibiting osteoclast activity.
Therapeutic effects:
  • Reversal/prevention of progression of osteoporosis with decreased fractures.

Classifications

Therapeutic Classification: bone resorption inhibitors

Pharmacologic Classification: biphosphonates

Pharmacokinetics

Absorption: 0.6% absorbed following oral administration (significantly by food).

Distribution: Rapidly binds to bone.

Protein Binding: 90.9–99.5%.

Metabolism/Excretion: 50–60% excreted in urine; unabsorbed drug is eliminated in feces.

Half-Life: PO: 10–60 hr; IV: 4.6–25.5 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
POunknown0.5–2 hrup to 1 mo
IVunknown3 hrup to 3 mo



Patient/Family Teaching

Pronunciation

i-BAN-dro-nate