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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: CARDIOVASCULAR COLLAPSE, arrhythmias, bradycardia, chest pain, hypertension, hypotension, tachycardia.

Derm: pruritus.

F and E: hypokalemia, metabolic acidosis.

GI: nausea, vomiting.

GU: urinary retention.

Hemat: METHEMOGLOBINEMIA, anemia.

MS: chondrolysis.

Neuro: circumoral tingling/numbness, paresthesia , SEIZURES, anxiety, dizziness, headache, rigors.

Resp: dyspnea.
Misc: (INCLUDING ANGIOEDEMA AND ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS , fever.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Surgical Anesthesia

Labor Pain

Postoperative Pain

US Brand Names

Naropin

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: epidural local anesthetics, anesthetics (topical/local)

Pharmacokinetics

Absorption: Systemic absorption follows epidural administration, but amount absorbed depends on dose.

Distribution: If systemic absorption occurs, this agent is widely distributed and crosses the placenta.

Metabolism/Excretion: Small amounts that may reach systemic circulation are mostly metabolized by the liver; <1% excreted unchanged in the urine.

Half-life: 4.2 hr (after epidural use).

Time/Action Profile

(analgesia)

ROUTEONSETPEAKDURATION
Epidural10–30 minunknown2–8 hr

†Duration of anesthetic block.

Patient/Family Teaching

Pronunciation

ROE-pi-vi-kane