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Indications

BEERS REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: QTc interval prolongation, HF.

Derm: photosensitivity.

GI: abdominal pain, diarrhea, vomiting, HEPATOTOXICITY, nausea, taste abnormality.

GU: ACUTE RENAL FAILURE, renal impairment.

Neuro: weakness.

Resp: PNEUMONITIS, PULMONARY FIBROSIS.
Misc: ANGIOEDEMA.

Interactions

Drug-Drug:

Drug-Natural Products:

Drug-Food:

Availability

Route/Dosage

US Brand Names

Multaq

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiarrhythmics

Pharmacologic Classification: benzofurans

Pharmacokinetics

Absorption: Poor bioavailability (4%) due to extensive first-pass hepatic metabolism (4%); food bioavailability (15%).

Distribution: Unknown.

Protein Binding: >98%.

Metabolism/Excretion: Undergoes extensive first-pass hepatic metabolism; mostly by the CYP3A isoenzyme. 6% excreted in urine as metabolites; 84% was excreted in feces as metabolites. Minimal elimination as unchanged drug.

Half-life: 13–19 hr.

Time/Action Profile

(antiarrhythmic effect)

ROUTEONSETPEAKDURATION
POunknown3–6 hr12 hr

†Steady state blood levels are attained at 4–8 days.

†Peak levels after individual doses.

Patient/Family Teaching

Pronunciation

droe-NED-a-rone