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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects

CV: ARRHYTHMIAS, hypotension, ECG changes

Derm: photosensitivity.

EENT: blurred vision, dry eyes, dry mouth

Endo: changes in blood glucose , gynecomastia

GI: constipation , hepatitis, paralytic ileus

GU: libido, urinary retention,

Hemat: blood dyscrasias

Metab: appetite , weight gain.

Neuro: lethargy, sedation.

Interactions

Drug-drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

US Brand Names

Surmontil

Action

  • Potentiates the effect of serotonin and norepinephrine in the CNS.
  • Has significant anticholinergic properties, including sedation.
Therapeutic effects:
  • Antidepressant action.

Classifications

Therapeutic Classification: antidepressants

Pharmacologic Classification: tricyclic antidepressants

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized by the liver via the CYP2D6 isoenzyme; the CYP2D6 enzyme system exhibits genetic polymorphism (7% of population may be poor metabolizers and may have significantly trimipramine concentrations and an risk of adverse effects). .

Half-Life: 7–30 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
PO2–3 wk (up to 30 days)2–6 wkdays–wks



Patient/Family Teaching

Pronunciation

trye-MIP-ra-meen