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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: heart failure.

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, itching, rash.

GI: HEPATOTOXICITY, anorexia, diarrhea, nausea, stomach pain, vomiting, drug-induced hepatitis, smell disturbance, taste disturbance.

Hemat: hemolytic uremic syndrome, neutropenia, pancytopenia, thrombotic thrombocytopenic purpura.

Neuro: depression, headache.

Resp: cough, nasopharyngitis.
Misc: fever.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

US Brand Names

LamISIL

Action

Therapeutic Effects:

Spectrum:

Classifications

Therapeutic Classification: antifungals (systemic)

Pharmacokinetics

Absorption: 70–80% absorbed after oral administration.

Distribution: Extensively distributed; penetrates dermis and epidermis; concentrates in stratum corneum, hair, scalp, and nails. Enters breast milk.

Protein Binding: 99%.

Metabolism/Excretion: Extensively metabolized by the liver by CYP1A2, CYP2C9, CYP2C19, and CYP3A4.

Half-life: Plasma — 22 days; longer from skin and nails.

Time/Action Profile

(antifungal tissue levels)

ROUTEONSETPEAKDURATION
POseveral daysdays–wkseveral wk

Patient/Family Teaching

Pronunciation

ter-BI-na-feen