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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema, hypotension.

EENT: pharyngitis, rhinitis, sinusitis.

F and E: hyperkalemia.

GI: abdominal pain, diarrhea, nausea.

GU: impaired renal function.

MS: arthralgia, back pain.

Neuro: dizziness, fatigue, headache.
Misc: ANGIOEDEMA.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Hypertension

Heart Failure

Post-Myocardial Infarction

US Brand Names

Diovan

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: angiotensin II receptor antagonists

Pharmacokinetics

Absorption: 10–35% absorbed following oral administration.

Distribution: Crosses the placenta.

Protein Binding: 95%.

Metabolism/Excretion: Minor metabolism by the liver; 13% excreted in urine; 83% in feces.

Half-life: 6 hr.

Time/Action Profile

(antihypertensive effect)

ROUTEONSETPEAKDURATION
POwithin 2 hr*4 wks24 hr

*After single dose.

†Chronic dosing.

Patient/Family Teaching

Pronunciation

val-SAR-tan