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Indications

High Alert

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: angina, arrhythmias, edema, HF, MI, QT interval prolongation, thrombophlebitis, TORSADES DE POINTES.

Derm: sweating.

EENT: blurred vision, cataracts, corneal keratopathy, dry eyes, glaucoma.

Endo: hot flashes.

F and E: hypercalcemia.

GI: nausea, HEPATOTOXICITY, vomiting.

GU: vaginal discharge, ENDOMETRIAL CANCER, endometrial hyperplasia/hypertrophy, uterine polyps, vaginal bleeding.

Hemat: anemia.

Neuro: depression, dizziness, headache, lethargy.

Resp: PULMONARY EMBOLISM.
Misc: tumor flare.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

US Brand Names

Fareston

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: antiestrogens

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed to tissues.

Protein Binding: 99.5%.

Metabolism/Excretion: Extensively metabolized; undergoes enterohepatic circulation.

Half-life: 5 days.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown3 hr4–6 wk

†Steady-state plasma concentrations occur after 4–6 wk.

Patient/Family Teaching

Pronunciation

TORE-em-i-feen