sipuleucel

Contraindicated in:

None.

Use Cautiously in:

Intended for autologous use only.

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypertension, peripheral edema

Derm: flushing, rash, sweating

GI: constipation, diarrhea, nausea, vomiting

GU: hematuria

Hemat: anemia

MS: back pain, joint pain, extremity pain, muscle spasms, musculoskeletal pain

Neuro: fatigue, headache, dizziness, insomnia, paresthesia, tremor

Resp: dyspnea

Misc: chills, fever, acute infusion reactions, citrate toxicity

Interactions ⬆ ⬇

Drug-drug:

Concurrent use of immunosuppressants may alter safety/efficacy.

Availability ⬆ ⬇

Suspension for IV infusion: minimum of 50 million autologous CD54⁺ cells activated with PAP-GM-CSF suspended in 250 mL lactated ringer's injection

Route/Dosage ⬆ ⬇

IV (Adults ): One dose every 2 wk for a total of 3 doses.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Autologous immunotherapy produced by collecting peripheral mononuclear cells during leukapheresis. Cells include antigen-presenting cells, which are activated during a culture period with prostatic acid phosphatase (PAP, an antigen found in prostatic cancer tissue) linked to granulocyte-macrophage colony-stimulating factor (GM-CSF, which activates immune cells). Induces an immune response against prostatic acid phosphatase.

Therapeutic effects:

↓spread of prostate cancer.

Classifications ⬆ ⬇

Therapeutic Classification: antineoplastics

Pharmacologic Classification: autologous cellular immunotherapies

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
IV	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Explain the purpose of sipuleucel and the importance of maintaining all scheduled appointments and adhering to preparation instructions for leukapheresis procedure to patient.
Inform patient that a central venous catheter may be required if adequate peripheral venous access is not available.
Advise patient to notify health care professional if fever over 100°F, swelling or redness around catheter site, pain at infusion or collection sites, symptoms of cardiac arrhythmia (chest pains, racing heart, irregular heartbeats), signs of acute infusion reaction, or persistent side effects occur.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products, especially immunosuppressive agents, being taken and consult health care professional before taking any new medications.

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Indications ⬇

Contraind./Precautions ⬆ ⬇