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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: MI

Derm: rash, STEVENS-JOHNSON SYNDROME

Endo: glucose intolerance

GI: diarrhea, nausea, vomiting, liver enzymes, abdominal pain

GU: nephrolithiasis

Hemat: neutropenia

Metab: body fat, hyperlipidemia, hypertriglyceridemia

Neuro: headache, fatigue, mood disorders

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA), immune reconstitution syndrome

Interactions

Drug-drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

Hepatic Impairment

US Brand Names

Lexiva

Action

  • Inhibits the action of HIV protease and prevents the cleavage of viral polyproteins.
Therapeutic effects:
  • Increased CD4 cell counts and decreased viral load with subsequent slowed progression of HIV and its sequelae.

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: protease inhibitors

Pharmacokinetics

Absorption: Fosamprenavir is a prodrug. Following oral administration, it is rapidly converted to amprenavir by the gut lining during absorption.

Distribution: Penetration into RBCs is concentration dependent.

Metabolism/Excretion: Primarily metabolized by the liver by the CYP3A4 isoenzyme. Minimal renal excretion.

Half-Life: 7.7 hr.

Canadian Brand Names

Telzir

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POrapid1.5–4 hr12–24 hr



Patient/Family Teaching

Pronunciation

fos-am-PREN-a-veer