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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: palpitations, tachycardia.

GI: abdominal pain, diarrhea, nausea.

MS: muscle cramps/soreness.

Neuro: headache, nervousness, tremor.

Resp: cough, paradoxical bronchospasm.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

Route/Dosage

Asthma

Prevention of Exercise-Induced Bronchospasm

COPD

US Brand Names

Serevent Diskus

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: bronchodilators

Pharmacologic Classification: adrenergics

Pharmacokinetics

Absorption: Minimal systemic absorption follows inhalation.

Distribution: Action is primarily local.

Metabolism/Excretion: Metabolized in the liver via the CYP3A4 isoenzyme; 60% excreted in feces, 25% excreted in urine.

Half-life: 3–4 hr.

Time/Action Profile

(bronchodilation)

ROUTEONSETPEAKDURATION
Inhaln10–25 min3–4 hr12 hr

†9 hr in adolescents.

Patient/Family Teaching

Pronunciation

sal-ME-te-role