IM (Adults and Children ): Transitioning from pegademase bovine weekly dose ≤30 units/kg or unknown: 0.2 mg/kg once weekly; may ↑ dose by increments of 0.033 mg/kg if trough adenosine deaminase activity <30 mmol/hr/L, trough deoxyadenosine nucleotides >0.02 mmol/L, and immune reconstitution not achieved. Transitioning from pegademase bovine weekly dose >30 units/kg: elapegademase dose (in mg/kg) (given once weekly) = pegademase bovine dose (in units/kg) /150; may ↑ dose by increments of 0.033 mg/kg if trough adenosine deaminase activity <30 mmol/hr/L, trough deoxyadenosine nucleotides >0.02 mmol/L, and immune reconstitution not achieved. Pegademase bovine-naïve: 0.2 mg/kg (based on ideal body weight or actual body weight, whichever is greater) twice weekly for ≥12–24 wk until immune reconstitution achieved, then ↓ dose to maintain trough adenosine deaminase activity >30 mmol/hr/L, trough deoxyadenosine nucleotides <0.02 mmol/L, and immune reconstitution.
US Brand Names⬆⬇
Revcovi
Action⬆⬇
Replaces adenosine deaminase. Without this enzyme, adenosine accumulates, which leads to apoptosis, lymphopenia, and opportunistic infections.
Therapeutic effects:
Increased lymphocyte concentrations.
Classifications⬆⬇
Therapeutic Classification: replacement enzyme
Pharmacokinetics⬆⬇
Absorption: Unknown.
Distribution: Unknown.
Metabolism/Excretion: Unknown.
Half-Life: Unknown.
Time/Action Profile⬆⬇
(plasma concentrations)
ROUTE
ONSET
PEAK
DURATION
IM
unknown
27–72 hr
unknown
Patient/Family Teaching⬆⬇
Explain purpose of medication to patient and caregiver. Emphasize importance of adherence to therapy.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking any new medications.
Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
