tapinarof

Contraindicated in:

Use Cautiously in:

OB: Safety not established in pregnancy;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: contact dermatitis, folliculitis, pruritus, urticaria

Neuro: headache

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Binds to and activates the aryl hydrocarbon receptor, which regulates cytokine and skin-barrier-protein expression and antioxidant activity. The specific mechanism for its effects in psoriasis is not known.

Therapeutic effects:

Classifications ⬆ ⬇

Therapeutic Classification: antipsoriatics

Pharmacologic Classification: Aryl hydrocarbon receptor agonists

Pharmacokinetics ⬆ ⬇

Absorption: Minimally absorbed.

Distribution: Unknown.

Protein Binding: 99%.

Metabolism/Excretion: Primarily metabolized by the liver.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(plaque reduction)

ROUTE	ONSET	PEAK	DURATION
Topical	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication. Advise patient to apply cream as directed; wash hands after use unless cream is applied to hands. Advise patient to read Patient Information before starting therapy.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.