tavaborole

Contraindicated in:

None.

Use Cautiously in:

OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Children <6 yr (safety and effectiveness not established);
Geri: Older adults may be more sensitive to drug effects.

Adv. Reactions/Side Effects ⬆ ⬇

Local: dermatitis, erythema, exfoliation, ingrown toenail

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

(Generic available)

Topical solution: 5%

Route/Dosage ⬆ ⬇

(Adults and Children ≥6 yr): Apply to affected nail once daily for 48 wk.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Inhibits fungal protein synthesis via inhibition of aminoacyl-transfer ribonucleic acid synthetase.

Therapeutic effects:

Resolution of toenail fungus.

Spectrum:

Active against Trychophyton rubrum and Trychophyton mentagrophytes.

Classifications ⬆ ⬇

Therapeutic Classification: antifungals

Pharmacologic Classification: oxaboroles

Pharmacokinetics ⬆ ⬇

Absorption: Minimal absorption follows topical administration.

Distribution: Unknown.

Metabolism/Excretion: Extensively metabolized; metabolites are eliminated mostly in urine.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(resolution of infection)

ROUTE	ONSET	PEAK	DURATION
Topical	unknown	unknown	48 wk‡

‡Length of treatment necessary for resolution of infection.

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes. Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes. Caution patient that solution is flammable; avoid use near heat or open flame. Discard bottle 3 mo after inserting dropper.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise patient to notify health care professional if area of application shows signs of persistent irritation (redness, itching, swelling, skin peeling, ingrown toenail).
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Indications ⬇

Contraind./Precautions ⬆ ⬇