ecallantide

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

OB: Other agents preferred for treatment of hereditary angioedema during pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Children <12 yr (safety and effectiveness not established);
Geri: Consider age-related ↓ in hepatic, renal, or cardiac function, concomitant diseases or other drug therapy in older adults; lower initial dose may be considered.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: pruritus, rash , urticaria

EENT: nasopharyngitis

GI: nausea, abdominal pain, diarrhea

Local: injection site reactions

Neuro: headache, fatigue

Misc: ANAPHYLAXIS, HYPERSENSITIVITY REACTIONS INCLUDING , fever

Interactions ⬆ ⬇

Drug-drug:

None noted.

Availability ⬆ ⬇

Solution for injection: 10 mg/mL

Route/Dosage ⬆ ⬇

SC (Adults and Children ≥12 yr): 30 mg given as three 10 mg injections; an additional dose of 30 mg may be given within 24 hr.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Acts as a selective, reversible inhibitor of kallikrein, thereby inhibiting its action in initiating bradykinin production, part of the cascade of events in hereditary angioedema (HAE).

Therapeutic effects:

Decreased severity of attack of HAE.

Classifications ⬆ ⬇

Therapeutic Classification: antiangioedema agents

Pharmacologic Classification: kallikrein inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following SUBQ administration.

Distribution: Unknown.

Metabolism/Excretion: Renally eliminated.

Half-Life: 2 hr.

Time/Action Profile ⬆ ⬇

(symptom improvement)

ROUTE	ONSET	PEAK	DURATION
SC	unknown	2–4 hr	up to 24 hr

Patient/Family Teaching ⬆ ⬇

Explain purpose for ecallantide and the need for administration by health care professional to patient. Advise patient to read Medication Guide prior to administration.
Caution patient of the risk for anaphylactic reaction usually within 1 hr of injection. Advise patient to notify health care professional immediately if signs and symptoms of anaphylactic reactions occur.
Inform patient that injection site reactions (local pruritus, erythema, pain, irritation, uriticaria, bruising) may occur.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise female patients to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Indications ⬇

Contraind./Precautions ⬆ ⬇