difluprednate (ophthalmic)

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Indications ⬇

REMS

Treatment of inflammation and pain associated with ocular surgery.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Active viral, mycobacterial or fungal infection of eyes and surrounding structures.

Use Cautiously in:

OB: Use in pregnancy only if potential benefit justifies potential risk to the fetus;
Lactation: Use cautiously during lactation;
Pedi: Safety and effectiveness in children have not been established.

Adv. Reactions/Side Effects ⬆ ⬇

EENT: ↑intraocular pressure, blepharitis, cataracts, conjunctival hyperemia, corneal edema, delayed healing, eye pain, infections, iritis, photophobia

Interactions ⬆ ⬇

Drug-drug:

None noted.

Availability ⬆ ⬇

Ophthamic emulsion: 0.05% in 5 mL bottle

Route/Dosage ⬆ ⬇

(Adults ): 1 drop four times daily, starting 24 hr after surgery for 2 wk, then twice daily for one week, then further tapered based on response.

US Brand Names ⬆ ⬇

Durezol

Action ⬆ ⬇

Decreases inflammation.

Therapeutic effects:

Decreased pain and inflammation following ocular surgery.

Classifications ⬆ ⬇

Therapeutic Classification: ocular agents

Pharmacologic Classification: corticosteroids

Pharmacokinetics ⬆ ⬇

Absorption: Limited systemic absorption.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
Ophth	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Instruct patient in correct technique and frequency for instillation of eye drops (see Medication Administration Techniques).
Instruct patient to avoid wearing contact lenses during therapy.
Advise female patients to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Advise patient to notify health care professional if redness, itching or inflammation develops or becomes aggravated.

Pronunciation ⬆

dye-floo-PRED-nate