satralizumab

Contraindicated in:

Hypersensitivity;
Active hepatitis B virus (HBV) infection;
Active or untreated latent tuberculosis (TB);
Active infection.

Use Cautiously in:

OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: cellulitis, pruritus, rash

EENT: nasopharyngitis

GI: gastritis, ↑liver enzymes, HBV reactivation, nausea

Hemat: thrombocytopenia, ↓fibrinogen, NEUTROPENIA

Local: injection site reactions

Metab: hypercholesterolemia, hypertriglyceridemia, weight gain

MS: ↑creatine kinase, arthralgia

Neuro: depression, fatigue, headache

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), INFECTION (INCLUDING TB)

Interactions ⬆ ⬇

Drug-drug:

May ↓ antibody response to and ↑ risk of adverse reactions to live-virus vaccines; do not administer concurrently.

Availability ⬆ ⬇

Solution for injection (prefilled syringes): 120 mg/mL

Route/Dosage ⬆ ⬇

SC (Adults ): 120 mg initially and then at Wk 2 and Wk 4; then 120 mg every 4 wk.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Acts as an interleukin-6 receptor antagonist.

Therapeutic effects:

Prolonged time to relapse.

Classifications ⬆ ⬇

Therapeutic Classification: none assigned

Pharmacologic Classification: interleukin antagonists, monoclonal antibodies

Pharmacokinetics ⬆ ⬇

Absorption: 85% absorbed following SUBQ administration.

Distribution: Minimally distributed to extravascular tissues.

Metabolism/Excretion: Metabolized to small peptides through catabolic pathways.

Half-Life: 30 days.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
SUBQ	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication to patient. Advise to read Patient Information before starting therapy. Instruct patient/caregiver on proper administration education, injection technique, and syringe disposal, if applicable.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Advise patient to complete any required live or live-attenuated vaccinations >4 wk and for non-live vaccines >2 wk before starting therapy.
Advise patient to notify health care professional if signs or symptoms of liver problems (dark urine, tiredness, ↓ appetite, upset stomach or pain, light-colored stools, vomiting, yellow skin or eyes) occur.
Inform patient to adhere to all necessary laboratory testing.
Advise patient to notify health care professional if any signs and symptoms of an infection occur.
Inform patient about hypersensitivity reactions, including anaphylaxis, and to seek immediate medical attention if symptoms occur.
Rep: Advise women of reproductive potential if pregnancy is suspected or planned or if breastfeeding. Health care providers should register patients and encourage pregnant patients to register for the pregnancy exposure registry that monitors pregnancy outcomes by calling 1-833-277-9338.

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Indications ⬇

Contraind./Precautions ⬆ ⬇