abacavir/dolutegravir/lamivudine

Contraindicated in:

Hypersensitivity to any component (especially abacavir; rechallenge may be fatal)
;
Resistance to any component;
Presence of HLA-B*5701 allele (↑ risk of potentially fatal hypersensitivity reaction)
;
Concurrent use of dofetilide;
Concurrent administration of lamivudine or abacavir alone or in other combination antiretroviral dose forms;
Severe renal impairment;
Hepatic impairment;
OB: Avoid use through 1st trimester of pregnancy (may ↑ risk of neural tube defects);
Lactation: Breastfeeding not recommended for patients with HIV.

Use Cautiously in:

Coinfected with hepatitis B virus (HBV) (severe acute exacerbations of HBV may recur after discontinuation of lamivudine)
;
Underlying HBV or hepatitis C (may worsen liver function);
Women and obesity (↑ risk of lactic acidosis and severe hepatomegaly with steatosis);
Underlying cardiovascular disease, including history of hypertension, hyperlipidemia, smoking history, or diabetes mellitus;
OB: Can consider use during 2nd or 3rd trimester if potential maternal benefit justifies potential fetal risk;
Pedi: Children <3 mo and <6 kg (safety and effectiveness not established).

Adv. Reactions/Side Effects ⬆ ⬇

CV: MI

GI: exacerbation of hepatitis B, HEPATOMEGALY (WITH STEATOSIS), HEPATOTOXICITY ( WITH HEPATITIS B OR C)↑ with hepatitis B or C)

Neuro: fatigue, headache, insomnia

Misc: HYPERSENSITIVITY REACTIONS, immune reconstitution syndrome

Interactions ⬆ ⬇

Drug-drug:

Alcohol may ↑ abacavir levels and the risk of toxicity.
Abacavir may ↓ levels and effectiveness of methadone; slight ↑ in methadone dosing may be needed.
Abacavir may ↑ levels and risk of toxicity of riociguat; may need to ↓ riociguat dose.
Combination therapy with tenofovir and abacavir may lead to virologic nonresponse; avoid concurrent use.
Dolutegravir may ↑ levels and risk of toxicity of dofetilide; concurrent use contraindicated.
Etravirine may ↓ levels and effectiveness of dolutegravir; should not be used concurrently without atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir.
Efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, and rifampin may ↓ levels and effectiveness of dolutegravir; ↑ dosage of dolutegravir recommended.
Nevirapine may ↓ levels and effectiveness of dolutegravir; avoid concurrent use.
Dolutegravir may ↑ levels and risk of toxicity of metformin.
Oxcarbazepine, phenobarbital, and phenytoin may ↓ levels and effectiveness of dolutegravir; avoid concurrent use.
Cation-containing antacids or laxatives, as well as buffered medications and sucralfate, may ↓ absorption and effectiveness of dolutegravir; give dolutegravir 2 hr before or 6 hr after these medications.
Calcium supplements (oral) or iron supplements (oral) may ↓ absorption and effectiveness of dolutegravir; under fasting conditions, abacavir/dolutegravir/lamivudine should be taken 2 hr before or 6 hr after these medications; when taken with food, abacavir/dolutegravir/lamivudine and calcium or iron supplements may be taken at the same time.
Dolutegravir may ↑ dalfampridine levels and risk of seizures.
Trimethoprim/sulfamethoxazole↑ levels and risk of toxicity of lamivudine; may need to alter dose of lamividine in renal impairment.
↑risk of pancreatitis with concurrent use of other drugs causing pancreatitis.
↑risk of neuropathy with concurrent use of other drugs causing neuropathy.
Sorbitol may ↓ levels and effectiveness of lamivudine; avoid concurrent use.

Drug-Natural Products:

St. John's wort may ↓ levels and effectiveness of dolutegravir; avoid concurrent use.

Availability ⬆ ⬇

(Generic available)

Tablets: abacavir 600 mg/dolutegravir 50 mg/lamivudine 300 mg
Tablets for oral suspension: abacavir 60 mg/dolutegravir 5 mg/lamivudine 30 mg

Route/Dosage ⬆ ⬇

Tablets and tablets for oral suspension are NOT interchangeable on a milligram-per-milligram basis.

PO (Adults and Children ≥3 mo and ≥25 kg): Triumeq: One tablet (abacavir 600 mg/dolutegravir 50 mg/lamivudine 300 mg) once daily; Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 50-mg dose of dolutegravir (Tivicay) is required separated from Triumeq by 12 hr.
PO (Children ≥3 mo and 20–<25 kg): Triumeq PD: Six tablets once daily (total dose = abacavir 360 mg/dolutegravir 30 mg/lamivudine 180 mg). Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 30-mg dose of dolutegravir (Tivicay PD) is required separated from Triumeq PD by 12 hr.
PO (Children ≥3 mo and 14–<20 kg): Triumeq PD: Five tablets once daily (total dose = abacavir 300 mg/dolutegravir 25 mg/lamivudine 150 mg). Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 25-mg dose of dolutegravir (Tivicay PD) is required separated from Triumeq PD by 12 hr.
PO (Children ≥3 mo and 10–<14 kg): Triumeq PD: Four tablets once daily (total dose = abacavir 240 mg/dolutegravir 20 mg/lamivudine 120 mg). Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 20-mg dose of dolutegravir (Tivicay PD) is required separated from Triumeq PD by 12 hr.
PO (Children ≥3 mo and 6–<10 kg): Triumeq PD: Three tablets once daily (total dose = abacavir 180 mg/dolutegravir 15 mg/lamivudine 90 mg). Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 15-mg dose of dolutegravir (Tivicay PD) is required separated from Triumeq PD by 12 hr.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Abacavir: Converted inside cells to carbovir triphosphate, its active metabolite. Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase, which in turn terminates viral DNA growth.
Dolutegravir: Inhibits HIV-1 integrase, which is required for viral replication.
Lamivudine: After intracellular conversion to its active form (lamivudine-5-triphosphate), inhibits viral DNA synthesis by inhibiting the enzyme reverse transcriptase.

Therapeutic effects:

Evidence of decreased viral replication and reduced viral load with slowed progression of HIV and its sequelae.

Classifications ⬆ ⬇

Therapeutic Classification: antiretrovirals (combination)

Pharmacologic Classification: integrase strand transfer inhibitors (INSTI) (dolutegravir), nucleoside reverse transcriptase inhibitors (abacavir, lamivudine)

Pharmacokinetics ⬆ ⬇

Abacavir

Absorption: Rapidly and extensively (83%) absorbed.

Distribution: Distributes into extravascular space and readily distributes into erythrocytes.

Metabolism/Excretion: Mostly metabolized by the liver; 1.2% excreted unchanged in urine.

Half-Life: 1.5 hr.

Dolutegravir

Absorption: Absorption follows oral administration; bioavailability is unknown.

Distribution: Enters CSF.

Protein Binding: >98.9%.

Metabolism/Excretion: Metabolized primarily by the UGT1A1 enzyme system with some metabolism by the CYP3A4 isoenzyme. 53% excreted unchanged in feces. Metabolites are renally excreted; minimal renal elimination of unchanged drug. Poor metabolizers of dolutegravir have ↑ levels and ↓ clearance.

Half-Life: 14 hr.

Lamivudine

Absorption: Well absorbed after oral administration (86% in adults, 66% in infants and children).

Distribution: Distributes into the extravascular space. Some penetration into CSF; remainder of distribution unknown.

Metabolism/Excretion: Mostly excreted unchanged in urine; <5% metabolized by the liver.

Half-Life: 13–19 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	unknown	24 hr

Patient/Family Teaching ⬆ ⬇

Emphasize the importance of taking Triumeq as directed. Must always be used in combination with other antiretroviral drugs. Do not take more than prescribed amount, and do not stop taking without consulting health care provider. Take missed doses as soon as remembered unless almost time for next dose; do not double doses. Advise patient to read the Medication Guide prior to starting therapy and with each Rx refill in case of changes.
Advise patient that discontinuing therapy may lead to severe exacerbations of HBV.
Instruct patient or caregiver in how to disperse Triumeq PD tablets.
Instruct patient not to share medication with others.
Inform patient that medication does not cure HIV or prevent associated or opportunistic infections. Medication may reduce the risk of transmission of HIV to others through sexual contact or blood contamination. Caution patient to use a condom, and avoid sharing needles or donating blood to prevent spreading HIV to others. Advise patient that the long-term effects of medication are unknown at this time.
Advise patient of potential for hypersensitivity reactions that may result in death. Instruct patient to discontinue medication and notify health care provider immediately if symptoms of hypersensitivity or signs of immune reconstitution syndrome (signs and symptoms of inflammation from previous infections) occur. A warning card summarizing symptoms of hypersensitivity is provided with each prescription; instruct patient to carry card at all times.
Instruct patient to notify health care provider immediately if symptoms of lactic acidosis (tiredness or weakness; unusual muscle pain; trouble breathing; stomach pain with nausea and vomiting; cold, especially in arms or legs; dizziness;fast or irregular heartbeat) or if signs of hepatotoxicity (yellow skin or whites of eyes, dark urine, light-colored stools, lack of appetite for several days or longer, nausea, abdominal pain) occur. These symptoms may occur more frequently in patients who are women, obese, or have been taking medications for a long time.
Instruct patient to notify health care provider promptly if signs of peripheral neuropathy or pancreatitis occur.
Advise patient to avoid sugarless gum or candy due to sorbitol content; may ↓ medication effectiveness.
Advise patient to notify health care provider of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care provider before taking other medications, especially methadone, St. John's wort, and other antiretrovirals.
Rep: May cause fetal harm and increase risk of neural tube defects. Advise adolescent and adult women of reproductive potential to use effective contraception and to avoid breastfeeding during therapy. Notify care provider if pregnancy is planned or suspected. Switch to another antiviral regimen during 1st trimester; may increase risk of neural tube defects. May consider Triumeq during 2nd and 3rd trimesters of pregnancy if expected benefit justifies potential risk to pregnant woman and fetus. Pregnant patients should be encouraged to enroll in the Antiretroviral Pregnancy Registry by calling 1-800-258-4263.
Advise patient to carry hypersensitivity warning card with them at all times.
Emphasize the importance of regular follow-up exams and blood counts to determine progress and monitor for side effects.

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Indications ⬇

Contraind./Precautions ⬆ ⬇