trimebutine

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

GI: diarrhea, dry mouth, dyspepsia, epigastric pain, nausea

Derm: hot/cold sensation, rash

Neuro: dizziness, drowsiness, dysgeusia, fatigue, headache

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

Action ⬆ ⬇

Therapeutic effects:

Classifications ⬆ ⬇

Therapeutic Classification: lower gastrointestinal tract motility regulators, spasmolytics

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Extensively metabolized; <2.4% excreted unchanged in urine.

Half-Life: 2.7–3.1 hr.

Time/Action Profile ⬆ ⬇

(symptom relief)

ROUTE	ONSET	PEAK	DURATION
PO	within 3 days–2 wk	1 hr (plasma concentrations)	>1 wk (following discontinuation)

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Advise to take as directed.
Advise patient to notify health care provider of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care provider before taking other medications.
Advise patient to avoid driving or operating heavy machinery until response to medication is known.
Advise patient to avoid alcohol use during therapy.
Advise patient to notify health care provider of persistent or worsening symptoms.
Rep: Advise women of reproductive potential to notify health care provider if pregnancy is planned or suspected or if breastfeeding.