viltolarsen

Contraindicated in:

None.

Use Cautiously in:

Renal impairment;
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding.

Adv. Reactions/Side Effects ⬆ ⬇

CV: ↓ejection fraction

Derm: urticaria

GI: abdominal pain, diarrhea, vomiting

GU: renal impairment

Local: injection site reaction

MS: arthralgia

Neuro: confusion

Resp: cough, upper respiratory tract infection

Misc: fever

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

Solution for injection: 50 mg/mL

Route/Dosage ⬆ ⬇

IV (Adults and Children ): 80 mg/kg once weekly.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Binds to exon 53 of dystrophin pre-messenger RNA (mRNA), resulting in exclusion of this exon during mRNA processing. Exon skipping allows for production of an internally truncated dystrophin protein.

Therapeutic effects:

Increased dystrophin production.

Classifications ⬆ ⬇

Therapeutic Classification: none assigned

Pharmacologic Classification: antisense oligonucleotides

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Extensively distributed to extravascular tissues.

Metabolism/Excretion: Not hepatically metabolized. Primarily excreted as unchanged drug in the urine.

Half-Life: 2.5 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
IV	unknown	1 hr (end of infusion)	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of viltolarsen. Advise patient to read Patient Information before starting therapy.
Explain need for continued medical follow-up to assess effectiveness and possible side effects of medication. Periodic lab tests may be needed.
Advise patient to immediately report signs or symptoms of kidney toxicity (nausea; vomiting; itchiness; urinating more or less than usual; foamy, bubbly, or bloody urine; swelling in the feet and ankles).
Advise patient to notify health care professional if signs and symptoms of infusion reactions (fever, chills or shivering, nausea, vomiting, diarrhea, tiredness, dizziness, sweating, hives, itching, shortness of breath, wheezing) occur.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Indications ⬇

Contraind./Precautions ⬆ ⬇