green tea

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

REMS

Bladder, esophageal, ovarian, and pancreatic cancer risk reduction, mental alertness, hypotension, cervical dysplasia associated with human papillomavirus infection, hyperlipidemia, weight loss, protection of the skin from sun damage, genital warts, dental caries, Parkinson's disease

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Allergy/hypersensitivity;
Pregnancy and lactation (doses >200 mg/day due to caffeine content).

Use Cautiously in:

Patients with caffeine sensitivity. Long-term use of doses >250 mg/day may produce tolerance, psychological dependence, tachyarrhythmias, and sleep disturbances;
Iron deficiency anemia (may worsen);
Diabetes (may impair glucose control);
Cardiac conditions (may induce arrhythmias in sensitive individuals);
Bleeding disorders.

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmia, tachycardia

CNS: agitation, dizziness, excitement, insomnia, tremors

GI: abdominal pain, diarrhea, hepatotoxicity, nausea, vomiting

F and E: hypokalemia

Endo: hyperglycemia

Hemat: prolonged bleeding time

Interactions ⬆ ⬇

Natural-Drug Products:

Green tea may ↓ effects of adenosine.
↑risk of bleeding with anticoagulants or antiplatelet agents.
↑effects of CNS stimulants.
May impair glucose control from antidiabetic agents.
Abrupt withdrawal can ↑ lithium levels.
May ↓ dipyridamole—induced vasodilation.
Verapamil can ↑ caffeine concentrations by 25%.
Additive effects with methylxanthines.

Natural-Natural Products:

↑risk of adverse cardiovascular effects with bitter orange.
↑risk of hepatotoxicity with hepatotoxic herbs or supplements.
↑risk of seizures, hypertension, or stroke with ephedra and creatine.

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

PO (Adults ): Range: 1–10 cups/day. One cup provides approximately 60 mg of caffeine.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Caffeine in green tea stimulates the CNS and cardiovascular system through adenosine receptor blockade and phosphodiesterase inhibition.

Therapeutic effects:

Improved cognitive performance and mental alertness.

Classifications ⬆ ⬇

Therapeutic Classification: central nervous system stimulants

Pharmacokinetics ⬆ ⬇

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

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Indications ⬇